![]() ![]() The pharmacodynamic consequences of benzodiazepine agonist actions include antianxiety effects, sedation, and reduction of seizure activity. Midazolam binds to the GABA receptor but does not displace GABA rather, it enhances the affinity of GABA for its receptor site on the same receptor complex. Midazolam, like other benzodiazepines, is presumed to interact with the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is widespread in the brain of humans as well as other species. ChemIDplus Lite Midazolam Hydrochloride Mechanism of action Evidence-based medicine for Chemical Defense - including efficacy and safety A. The anticonvulsant midazolam has been shown to be effective against both convulsant (e.g., picrotoxin, hydrazine, strychnine, tetramethylenedisulfotetramine) and cholinergic (e.g., sarin (GB), soman (GD), cyclosarin (GF), tabun (GA), VX, and organophosphorus pesticides) agents by enhancing the inhibitory effect of gamma-aminobutyric acid at GABA(a) receptors and limiting excess central nervous system excitation and seizures. Chemical Defense therapeutic area(s) - including key possible uses Name of Chemical Defense therapeutic agent/device ![]()
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